PradalexTM (pradofloxacin injection)

Pradalex (pradofloxacin injection) by Elanco

PradalexTM (pradofloxacin injection)

For the treatment of swine respiratory disease (SRD) associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae (M. hyo).

SRD Powerhouse

Quick.*
Dual Action.
Convenient.

Bottle Size

100 mL; 250 mL

: SRD Powerhouse
Quick.*
Dual Action.
Convenient.
: Bottle Size
100 mL; 250 mL

MODE OF ACTION

As a new, third-generation fluoroquinolone, Pradofloxacin has a unique structure that differs from any other molecule in the class. Pradalex’s mode of action has an equal affinity to both DNA gyrase and topoisomerase IV, resulting in a dual targeting effect and increased potency relative to other fluoroquinolones.

This image shows the bacteria in replication with the DNA

In bacterial replication, the enzyme DNA gyrase unfolds the bacterial DNA for replication by DNA polymerase.

This image shows the enzyme separates the identical DNA copies into sister cells.

Afterward, the enzyme topoisomerase IV separates the identical DNA copies into sister cells.

This image shows how Pradalex works by simultaneously binding and inactivating inhibiting bacterial replication.

Pradalex works by simultaneously binding and inactivating both DNA gyrase and topoisomerase IV inhibiting bacterial replication.

This image shows the chromosome fragmenting which results in rapid cell death.

This causes the chromosome to fragment and results in rapid cell death.

Dosage and Administration

Administer once as an intramuscular injection in the neck at a dosage of 7.5 mg/kg (1.7 mL/100 lbs) body weight. Do not inject more than 5 mL (290 lbs) per intramuscular injection site.

Industry-leading 2-day withdrawal period.

Single-dose, low-volume antibiotic with exceptional syringeability³

Pradalex Overview

A Powerful SRD Punch

Pradalex is an SRD antibiotic treatment that reaches twice the concentration in a third of the time^1,2 — achieving peak serum activity within 45 minutes after injection.
Featuring a unique molecular structure and mode of action, Pradalex simultaneously blocks two enzymes responsible for bacterial replication within the bacteria nucleus, leading to improved potency and broad-spectrum efficacy relative to other injectable antibiotics.
Pradalex is a convenient, one-shot, low-volume antibiotic with a 2-day withdrawal period, offering SRD treatment protocol flexibility from nursery to finish.

Pradalex by Elanco (pradofloxacin injection)

Pradalex Product Label

Read the full label for important use and safety information.

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INDICATIONS:

Pradalex is indicated for the treatment of SRD associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis and Mycoplasma hyopneumoniae in weaned swine intended for slaughter (nursery, growing, and finishing swine, boars intended for slaughter, barrows, gilts intended for slaughter, and sows intended for slaughter). Not for use in swine intended for breeding (boars intended for breeding, replacement gilts and sows intended for breeding) and in nursing piglets.

DOSAGE AND ADMINISTRATION:

Swine: Administer once as an intramuscular injection in the neck at a dosage of 7.5 mg/kg (1.7 mL/100 lb) body weight. Do not inject more than 5 mL per intramuscular injection site.

IMPORTANT SAFETY INFORMATION:

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in humans. Keep out of reach of children. Avoid contact with eyes and skin. Individuals with a history of hypersensitivity to quinolones should avoid this product. Not for use in animals intended for breeding because the effects of Pradalex on swine reproductive performance, pregnancy and lactation have not been determined. Not for use in nursing piglets because safety and effectiveness have not been demonstrated. Quinolones should be used with caution in animals with known or suspected central nervous system (CNS) disorders. Mild to moderate inflammatory changes of the injection site may be seen in swine treated with Pradalex. See package insert for additional safety information.

PradalexTM (pradofloxacin injection)

PradalexTM (pradofloxacin injection)

Key Features

Dosage

MODE OF ACTION

Dosage and Administration

Industry-leading 2-day withdrawal period.